Tabriz University of Medical Sciences Journal of Cardiovascular and Thoracic Research 2008-5117 18 2 2026 06 30 Association of Value of Fibrosis-4 Index with Long-Term Mortality in Patients with Heart Failure: A Comparison Study with Fibrosis-5 Index 103 108 10.34172/jcvtr.33476 EN Halit Emre Yalvaç https://orcid.org/0000-0003-2620-9948 Fatih Enes Durmaz https://orcid.org/0000-0002-9688-110X Bektaş Murat https://orcid.org/0000-0002-6564-7185 Selda Murat https://orcid.org/0000-0002-3935-0222 Journal Article 10.34172/jcvtr.33476 2025 01 06 2026 02 18 Introduction: Fibrosis-4 (FIB-4) and fibrosis-5 (FIB-5) indices are non-invasive biomarkers originally developed for hepatic fibrosis but may reflect systemic pathophysiological changes related to adverse cardiovascular prognosis. We aimed to investigate whether baseline FIB-4 and FIB-5 values predict long-term mortality in patients with heart failure (HF). Methods: This retrospective observational study included 593 patients with HF who had available long-term mortality data. FIB-4 and FIB-5 indices were calculated at admission. Patients were followed for all-cause mortality, and outcomes were evaluated at 1-year, 3-year, and 5-year intervals. Clinical, laboratory, and echocardiographic parameters were compared between survivors and non-survivors. Results: During follow-up, 1-year, 3-year, and 5-year mortality rates were 24.6%, 39.0%, and 49.7%, respectively. Non-survivors had significantly higher FIB-4 and FIB-5 values compared with survivors (P<0.001 for both). ROC curve analyses demonstrated that both indices had significant predictive performance for long-term mortality. Optimal cut-off values showed good sensitivity and specificity for identifying high-risk patients. Conclusion: Higher FIB-4 and FIB-5 values are associated with greater long-term mortality risk in HF patients. These indices may serve as practical, cost-effective prognostic biomarkers for mortality risk stratification in routine clinical care.